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It's been a long time since I watched HBO's True Blood.  And even longer since I've watched the first episode(s).  But, as I recall, that's a problem Anna Paquin's Sookie Stackhouse character had: difficulty blocking out everyone else's thoughts.  Working as a waitress in a crowded restaurant and being bombarded with what everyone was thinking.

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Star Trek TNG handled this well in the episode Tinman where we meet the Federation’s most powerful telepath, and find out he was patient at a psychiatric hospital when Troi was interning because he could not turn off background thoughts.

On just about every other episode of Star Trek, whatever latest attack attempted on the crew didn't affect a Vulcan in the same way if at all. Maybe that could be the same with telepathy, where the neurological constitution of a Kryptoonian would be just different enough to render any attack ineffective. Or maybe it was established at some point that the only difference is the red sun/yellow sun cell charging capability. Fun for thought :)

Besides, now that I think about it, it's been established that Xavier's powers had worked on other Marvel alien races in the past - the Z'nox and the Shi'ar in particular - but it has been said that it was more difficult as a result.