Howard the Duck?  Nope!  Miss the big bill (and more).

Aquaman, Power Girl, Huntress, Hawkman?  I don't even know their origins anymore.

Green Arrow? We'll never see poor old Ollie (the Neal Adams version) again.

Superman and Batman? Both dads (and both psychologically far from the iconic versions).

Hulk and Thor? Which version? Which MIND?
Moon-Knight? Not anywhere close to the Moench/Sienkiewicz masterpiece.

Tigra?  Is Tigra the same?

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Yes, just recently I was reading again an article with J.M Dematteis on the origins of his 'Kraven's Last Hunt' story and he admitted that it started off as a Simon Williams tale, which was rejected, then he tried pitching it a couple of times as Batman story, which were also rejected. Then he finally got it approved as a plot for Spider-Man.*

Made me wonder how often that sort of thing happens? Pitches for one character that end up getting used for another.

*Admitedly I really liked Kraven's Last Hunt though. As it did seem to work well for Mike Zeck's artwork on Spider-Man with the Black Costume of the time. (I don't think the one off 'horror vibe' of the tale would have worked quite as well with the regular Spider-Man costume.)

In terms of characters who don't seem to have been changed much it is a struggle to find any.

The only one I can think of, off the top of my head, is DC's Stargirl. And I'm not sure if folks would consider her as being around long enough, to qualify as a suitable answer to this topic's question. (1999? I suppose that is 25 years now.)

I have the sneaking suspicion though that because of the real life origins for the character's inspiration (As a tribute to Geoff John's tragically deceased sister, Courtney) that this may have waranted a hands off policy for other creators in messing with her.

Of course she is something of a legacy character herself. So I suppose it could be argued that she already is the altered version of the original character.