I disagree entirely

I also think people underestimate how much MJ means to many girls out there, my sister included (and to a much much  smaller degree, my wife).

Once the rough patch is over you simply ignore the fact he was ever married in the first place. Howard Mackie on Amazing did a great job of undoing the marriage without undoing it. By the end of his tenure the book had the anything can happen feel of Spider-Man books of days past. I've only seen one writer who wrote a good married Spider-Man and that was Roger Stern.

The problem with the marriage is it adds nothing to the Spider-Man mythos. I can't think of one good Spider-Man story in the past twenty years, that would not have been just as good or better if he were single.

Does MJ have to be married to Peter in order for her to be important to your wife and sister?
***

Who am I, Uatu the Watcher? 

I'm not mindreading.  My sister is a huge MJ fan and a big fan of the relationship (although she also likes Gwen Stacy a lot too).  She even bought the two MJ novels (albeit they are not married in them-it is a pseudo Ultimate Spidey continuity).  She loves the Parellel Lives graphic novel, the Wedding TPB, and is a big Spider-man reader.

My wife is not as easy to make read a comic, but prefers reading the marriage stuff to any of the superheroics. (Action scenes in movies bore her too-when say Obi-Wan and Anakin have a lightsaber fight in SITH, that's when her eyes glaze over and she gets bored.  Of course, that's when I get most pumped up). Which is partly why if she is going to read a comic, she prefers Spider-man to any of the others.

This would not have to be a question at all, of course, if more people worked to serve the character rather than striving to leave their "mark" on him.

Archeology 101. And, like 99% of archeology, just about as dry and dull.

Once the rough patch is over you siply ignore the fact
he was ever married in the first place.

****

Considering Gwen Stacy is brought up every two weeks-she died 15 years before I started reading yet the first Annual I read focused on her and her clone-doubt this would happen.

I don't think you can ignore it anyway-since probably 2/3 of current readers like it.  And I would bet the number of issues of Spidey books with him married outnumber the # with him not married. He's been married 20 of 45 years now, and has had many more books post 1987 then pre-1987.

I have no problem with the marriage but understand how for potential new and young readers the character at present holds no relevance.  If a return to his original status is required, fair enough, just as long as nobody is killed off in the process. 

One thing I can't stand as a longtime reader is so-called hot writers coming in and making their mark on books by killing off long established that they had no hand in creating.  The biggest worry is that the current writer of ASM is actually writing this and his track record speaks for itself, he doesn't seem to get Spider-man.

On the other hand, maybe I needn't worry at all since Quesada himself is supposed to draw it, so by the time it comes out I'll probably be dead or in an old folks home and no longer care.