THE THING VS ABOMINATION

Has this been done? I don't recall it. If the Hulk is stronger than the Thing, and the Abomination once cleaned Hulk's clock, methinks Thing could struggle against Abomination.

HULK VS FRIGHTFUL FOUR

Not sure if this has been done. Be interesting to see the Hulk wipe the floor with them. ;-)

THOR VS DR. OCTOPUS

If Octopus upgraded and had something like the adamantium tentacles, he could probably give Thor some trouble.

SPIDER-MAN VS GREY GARGOYLE

All those puns and webs won't help the web-slinger if the Grey Gargoyle touches him, eh? How can Spider-Man defeat him?

IRON MAN VS JUGGERNAUT

Better come up with a new armour, Mr Stark!

X-MEN VS MODOK

Can't recall if this has been done, either. Be fun visually and conceptually.

DAREDEVIL VS RED SKULL

Be interesting to see Daredevil, away from New York, against Skull in a remote location.

CAPTAIN AMERICA VS MAN-BULL

I feel this'd be an interesting punch-up.

And I'll end with Namor VS Sinister Six. Namor is a tough cookie, but six supervillains may give him a challenge!

I do not have an exhaustive knowledge of comic battles, but I have used Google images over time. I've not been able to find any record of contests such as Thing VS Abomination or FF VS Leader. I'm guessing they haven't happened.

"Cross-pollination" has been done, of course. It should never be overdone. But it has been done. Despite that, some battles do not seem to have happened.

I am surprised that Kraven the Hunter, relishing a challenge, hasn't ever gone after the Lizard, to be honest.

Attuma has a track record of kidnapping attractive redheads from the surface world... Ben's not going to be happy about that.

THE AVENGERS VS. HELA

Captain America falls in battle against Loki and an army of Frost Giants. As he fell on an Asgardian battlefield, Hela lays claim to his soul. The Avengers will not allow that to stand.

SPIDER-MAN VS. THE U-FOES

Can't he get along with any version of the Fantastic Four?

KITTY PRYDE VS. NIGHTSHADE

Nightshade has developed an airborne contagion that turns mutants into werewolves. The X-Men have all fallen victim to it along with the Professor. Kitty has to remain phased (breaking down the covalent bonds in the formula molecules as she moves through them) to stay unaffected. What hope does a ghost have against a mansion full of slavering, hyper-violent werewolves?

Thor vs the Abomination - just for a good ol' fashioned knock down drag out slug fest.

Iron Man vs Machinesmith - It'd be fun to see how Tony manages to keep control of his armor.

Hawkeye vs Bullseye - the battle of the Eyes! "I'm magic!" "Yeah, well let's see you pull THIS out of a hat!" TWANNG!

Daredevil vs Mysterio - who can figure whom out first?

The Defenders (Doc, Hulk, Kyle, Namor, and Val) vs the Masters of Evil (from the Avenger "Siege" storyline. They nearly beat Hercules to death... but how would they handle the Hulk?)

Dr. Strange vs the Impossible Man - just for deadly serious vs. impiously humorous.

Marvel Team-Up: Spider-Man and the original X-Men vs the Squadron Sinister. Minus Professor X... maybe.

The Fantastic Four vs  The Headmen - a really weird group up against Marvel's First Family might produce some interesting dynamics.

She-Hulk vs Deadpool - Look, if we're gonna break the fourth wall...!

The Hulk vs the Brute - was the Brute powerful enough and smart enough combined to take on the Hulk?

Just a few crazy ideas.... enjoy.

You know, I'd rather see something fresh done in one issue (e.g. Kraven VS Lizard or Kraven VS Beast) than another six-issue arc featuring a battle that has already been done!