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I know little, but I thought they only affected living beings (I suppose the ground would suffer some collateral damage). 

I remember asking the school librarian if she books on gamma radiation after watching the Bixby/Ferrigno series.

And I did research magnetism and electricity once because I was wondering how Iron Man would fare against Electro.

From time to time, even as an adult, I've looked up science when reading adventures featuring the likes of Darkseid's Omega Beams. Sounds geeky, I know.

I did read up on cosmic rays, gamma rays, etc. My mum worked in a hospital as a healthcare assistant - and I remember asking her about radiation in general. She talked about medical applications and the like.

I was primarily interested in the superhero exploits, but the scientific stuff was a useful by-product of my comic reading.

I think the scale should be determined by the relative power levels.

So, Darkseid's Omega beams vs...

Spider-Man - complete obliteration, as noted.

Iron Man - The most current armor might allow that the armor would disappear, leaving behind one very vulnerable Tony Stark.

Silver Surfer or Superman - Probably wouldn't eliminate them, but it would knock 'em for a loop.

Galactus or Odin - It would damage them, but not kill them or knock them around.

Darkseid - Assuming the redirection or reflection, it has devastated him, but not destroyed him - likely the same results as with Superman or the Surfer.

These are generalities. For specifics - say, Darkseid vs Dormammu - it would depend on the story around it. Whichever result best served the story would be the expected outcome. After all, didn't Ka-Zar once beat Thanos, and Squirrel Girl triumph over Dr. Doom?

Nothing could be further from the truth. As my record shows, it's all about FUN. Nothing more, nothing less.

I just smile at the thought of Galactus consuming the energies of Dormammu's Dark Dimension - or Destroyer surviving Darkseid's Omega Beams. It's not about quantifying anything or being anal, it's simply about imaging such scenarios.