How about we re-imagine it here?

It's quite simple. Pick the heroes who were originally part of the arc and match them against villains who've they've rarely or never battled previously. Use as many heroes as you like, but they must be ones who featured in the original series.

Mine would be:

Not the most creative choices, perhaps, but it's a subjective topic.

I liked Spider-Man's battles against Doom. I'd welcome him battling someone else with delusions of grandeur in Mandarin.

I'd like to see Iron Man's armour put to the test against Abomination!

Thor VS Sauron would be a visual treat for me. Watch out for Mjolnir, Sauron! 

Have X-Men ever fought Kang? It could be their biggest challenge, given how close he's come to defeating the Avengers.

Good luck against the Blob, Captain America!

One man he may be, but the FF would be advised not to touch Grey Gargoyle. They'd probably subdue him relatively easily, though.

I chose Sandman as a Wolverine opponent because all of Wolverine's skills appear useless against Sandman! Adamantium claws aren't much use against Sandman's powers!

I'm also not sure how much use Hulk's strength would be against Molecule Man's powers, but the green-skinned goliath would no doubt find a way to persevere.

I'd like to see Mister Sinister's mental powers used against Daredevil's own super-senses!

Has Dr. Strange ever fought Thanos? Is Thanos well-protected against magic? Let's find out.

And in perhaps another mismatch, Punisher would have an incredibly tough time against Magneto.

Like I said, all subjective, but over to you!

And it would be fun to see stories with the Sinister Six against most of these heroes!  Together, they're powerful enough to be trouble for Iron Man; and yet, matching them against Daredevil could be quite a tale too.

There are no doubt lots of stories we haven't seen. I don't know for sure, but I don't recall Fantastic Four ever having faced Juggernaut. I'd love to see that.

It's the fresh spin that appeals to me. The fresh angle. Such as Cap VS Vulture. Cap is probably stronger than Vulture (I assume Vulture has no specific super-strengths). However, Cap caught in mid-air with the Vulture is, well, it's a long drop, isn't it?

It's the little things that can be fresh with a new opponent. Vulture can avoid Spider-Man's webs - but can he avoid Cap's shield? Is Iron Man adequately protected against Electro's powers? 

I like the idea of characters (good and bad) being taken out of their natural environment. Scorpion may enjoy beating on Spider-Man atop a roof - but how would he fare dragged underwater by Namor? 

The slightest bit of cross-pollination could lead to some interesting places. How would a particular character, perhaps used to fisticuffs, handle an opponent who primarily uses weapons or gadgets? 

I'm thinking about comfort zones here. Namor usually engages in fisticuffs with villains, but how would he handle a villain who uses mainly weaponry? How would Vulture handle a hero who can fly after him? Just how good is Reed Richards' science going to be against Dormammu or Juggernaut?